Self-Assembled Monolayers (SAMs) and gold surface modification using functionalized alkane thiols and bipodal alkane thiols based on heterobifunctional thiol alkane PEG and dithiol alkane aromatic PEG hydroxyl, carboxylate, hydrazide and biotinylated linkers/tethers for Biosensors, Nanoparticles, Imaging AFM, Microfluidics and Cryo-electron microscopy, plus cinnamaldehyde and stilbene derivative products.  

Research therapeutics for Photodynamic Therapy (laser-activated photosensitizers).  Photodynamic therapy (PDT), the treatment of disease with light and a light-activated therapeutic agent, has made strides towards a more general clinical acceptance over the past decade, but still has not reached the stage where it is recognized as a first line or primary treatment for solid subcutaneous cancerous tumors by most clinicians, including most surgeons and radiation oncologists. Until now.

In our proposed extension of the Phase II contract research, we will use Image-guided targeted one- and two-photon photodynamic therapy (TTPDT) to pursue veterinary clinical trials leading to an INDA application to FDA for treatment of small cell carcinomas in cats for whom there are no viable options.  We will also initiate animal clinical trials leading to an application for human clinical trials of our optimized therapeutic regime, developing a turn-key outpatient treatment for recurring refractory head and neck cancer that will replace current debilitating cancer treatments.